AKR1B10 and neoplasm: Therefore, we demarcated the patients according to AKR1B10 expression levels, and found that the survival of AKR1B10neg patients was significantly worse compared to the AKR1B10pos group (P < 0.05; Figure 1F–1G, Supplementary Figure 1C), regardless of age, gender, tumor size, tumor location, venous invasion, neural invasion and lymph node metastasis.