In addition, AKR1B10 expression was significantly associated with the depth of invasion (P < 0.05), lymph node invasion (P < 0.001) and TNM staging (P < 0.001, Table 1), while no correlation was observed with other clinicopathological variables such as age, gender, tumor size, tumor location or degree of differentiation (P > 0.05; Table 1). The gene discussed is AKR1B10; the disease is neoplasm.