AKR1B10 and colorectal carcinoma: Univariate analysis further revealed that low AKR1B10 expression (P < 0.001), lymph node invasion (P < 0.001), degree of differentiation (P < 0.01), depth of invasion (P < 0.001) and TNM staging (P < 0.001, Table 2) were related to poor prognosis, and low AKR1B10 expression was confirmed as an independent prognostic factor for the survival of CRC patients by multivariate analysis (P < 0.001, Table 2).