To gain further mechanism insights, we analyzed the FGF1 levels in CRC cells transfected with AKR1B10-shRNA or AKR1B10 overexpression plasmid, and found that AKR1B10 downregulated FGF1 while knocking it down had the opposite effect (Figure 5A). The gene discussed is FGF1; the disease is colorectal carcinoma.