The capillary-like tube formation of endothelial cells in vitro, as well as western blot analysis for quantification of tumor angiogenic factors tissue inhibitor of metalloproteinases 2 (TIMP-2), vascular endothelial growth factor (VEGF), and vascular endothelial (VE)-cadherin, was applied (Figures 7A–7D). Here, TIMP2 is linked to neoplasm.