TIMP2 and neoplasm: Moreover, overexpressed miR-4500 brought about a decline in the expressions of migration- and invasion-related factors MMP-2 and MMP-9; proliferation-related factors Ki67 and PCNA; and tumor angiogenic factors TIMP-2, VEGF, and VE-cadherin; meanwhile, the expression levels of apoptosis-related factors c-caspase-3/t-caspase-3 and c-caspase-9/t-caspase-9 were significantly elevated.