Whether the differences between the two murine BCC models are a due to overexpression of the mutant SmoM2 oncogene, which itself might be immunogenic or a result of SMO‐independent roles of Ptch1 as dependence receptor [50] and binding partner cell cycle regulators such as Cyclin B [51] remains to be addressed. Here, PTCH1 is linked to skin basal cell carcinoma.