Given the exceptionally high mutational burden of human BCC [47], we here hypothesized that (a) HH/GLI‐induced human BCC is immunogenic, (b) HH/GLI signaling establishes an immunosuppressive tumor microenvironment, and (c) HH/GLI‐driven BCC is susceptible to immunotherapy. Here, GLI1 is linked to skin basal cell carcinoma.