In line with the expression of IL10 and TGFβ, we show increased numbers of Treg cells in PtchΔep tumors, similar to human BCC, where Omland et al. [70] provided evidence that active HH/GLI signaling can induce Treg accumulation along with a strong increase of TGFβ expression. The gene discussed is GLI1; the disease is skin basal cell carcinoma.