Together with previous reports on the role of HH/GLI in gastric cancer showing PD‐L1 upregulation by HH/GLI signaling [59, 73], our findings in BCC suggest that HH/GLI‐mediated induction of the PD‐L1/PD‐1 immune checkpoint may represent a more general mechanism of HH‐mediated immune escape in cancer. Here, GLI1 is linked to skin basal cell carcinoma.