It is caused by heterozygous, pathogenic variants affecting the DNA MMR genes, MLH1, MSH2, MSH6, or PMS2. MUTYH‐associated polyposis (MAP; OMIM#608456) is a recessively inherited CRC syndrome caused by biallelic variants in the base‐excision repair gene MUTYH. The potential of monoallelic, pathogenic MUTYH variants to predispose to CRC remains debatable.1 This evidence concerns the gene MUTYH and colorectal carcinoma.