Twenty‐two rare variants were shared by the three patients (Tables 1 and S1), including variants in the MSH6 (NM_000179.2: c.3299C > T, p.Thr1100Met) and MUTYH (NM_001128425.1: c.536A > G, p.Tyr179Cys) genes, while the other 20 genes could not be clearly linked to cancer predisposition. This evidence concerns the gene MSH6 and cancer.