MSH6 and colorectal carcinoma: It is caused by heterozygous, pathogenic variants affecting the DNA MMR genes, MLH1, MSH2, MSH6, or PMS2. MUTYH‐associated polyposis (MAP; OMIM#608456) is a recessively inherited CRC syndrome caused by biallelic variants in the base‐excision repair gene MUTYH. The potential of monoallelic, pathogenic MUTYH variants to predispose to CRC remains debatable.1