ROR2 expression is often dysregulated in human cancers, and increased ROR2 levels promote tumor growth, migration, and invasion in multiple cancers including hepatocellular carcinoma [4], non-small cell lung cancer [5], cervical cancer [6], pancreatic cancer [7], melanoma [8, 9], colon cancer [10], head and neck squamous cell carcinoma [11], and breast cancer [12]. Here, ROR2 is linked to malignant colon neoplasm.