Risk factors for ESRD were early-onset type 2 diabetes (odds ratio [OR], 2.27 [95% CI, 1.21–4.28]; P = .011), duration of diabetes (OR, 1.07 [95% CI, 1.03–1.11]; P < .001), history of hypertension (OR, 3.81 [95% CI, 1.62–8.98]; P = .002), SBP (OR, 1.02 [95% CI, 1.01–1.03]; P = .001), use of insulin therapy (OR, 3.16 [95% CI, 1.53–6.53]; P = .002), and use of antihypertensive drugs (OR, 3.78 [95% CI, 1.76–8.08]; P = .001). The gene discussed is INS; the disease is diabetes mellitus.