To define the signalling pathways involved in the mindin‐mediated regulation of colorectal cancer cell proliferation, we analysed the protein expression of ERK/p‐ERK and NF‐κB/p‐NF‐κB in the mindin overexpression or knock‐down CMT93 and CT26 WT cell lines and the control cell lines. Here, SPON2 is linked to colorectal cancer.