APOE and open-angle glaucoma: In the combined NEIGHBOR-MEEI data set, APOE ε4 was inversely associated with POAG overall (odds ratio [OR], 0.83; 95% confidence interval [CI], 0.74–0.94; P = 0.0022) and in both the HTG (OR, 0.81; 95% CI, 0.70–0.94; P = 0.0052) and NTG (OR, 0.71; 95% CI, 0.58–0.87; P = 0.0014) subgroups (Table 1).