ATXN2 and amyotrophic lateral sclerosis: For example, some of the same genes that harbor known risk alleles for amyotrophic lateral sclerosis (ALS), such as optineurin (OPTN), TANK-binding kinase 1 (TBK1), and ataxin2 (ATXN2), have also been shown to confer genetic risk in glaucoma.2