FCGR2B and malaria: Interestingly, the human FcγRIIb-232T allele, in which an isoleucine residue in the transmembrane domain of the receptor is replaced with a threonine residue, resulting in an altered plasma membrane localization and decreased receptor function, was shown to be enriched in areas with malaria (Clatworthy et al., 2007; Waisberg et al., 2011; Willcocks et al., 2010).