In contrast, Klippel–Trenaunay syndrome is a sporadic congenital vascular malformation with the most common somatic PIK3CA mutations as well as infrequent KRAS mutations, and distinguished by extensive port‐wine stains involving limbs and/or trunk associated with hypertrophy of soft tissue or bone and venous varicosities.2, 3. Here, KRAS is linked to vascular malformation.