Therefore, the current WHO classification includes all B cell lymphomas with rearrangements of C-MYC and BCL2 and/or BLC6 into the category of high-grade B cell lymphomas with rearrangements of C-MYC and BCL2 and/or BLC6 (HGBL with MYC and BCL2 and/or BCL6 rearrangement) irrespective of morphology, while lymphomas without rearrangement, which would otherwise fit into the former category of BCLU, are now summarized as HGBL, NOS [12]. The gene discussed is MYC; the disease is B-cell non-Hodgkin lymphoma.