MGMT and cancer: It seems that genotype and molecular features of diffuse gliomas, such as the presence of H3 K27M-mutant, IDH wildtype, O-6-methylguanine-DNA methyltransferase methylation, or -according to last research- even excitatory synapse between neurons and cancer cells, are more important aspects to take into account for analyzing survival rates in diffuse pineal region gliomas [21–25].