Willis et al. (2020) showed that IL-6 induces neuroprotection in neurons following traumatic brain injury by a trans-signaling mechanism. MCP-1 seems to mediate the crosstalk between DRG neurons and macrophages, inducing neurite outgrowth, and mobilizing M2 macrophages (Kwon et al., 2015). The gene discussed is CCL2; the disease is injury.