miRNAs from the DLK1-DIO3 locus have been shown to promote pluripotency by inhibition of differentiation and stimulation of self-renewal in mouse ES cells (Moradi et al., 2017) and were found to be increased in tumor-originating cancer cells from lung adenocarcinoma (Valdmanis et al., 2015). This evidence concerns the gene DLK1 and neoplasm.