Many studies suggest MEG3 as a tumor suppressor, largely due to the observation that MEG3 expression is lower in tumor tissue compared to normal tissue (Sheng et al., 2014; Sun et al., 2014, 2016; Yin et al., 2015; Chak et al., 2017; Molina-Pinelo et al., 2018). Here, MEG3 is linked to neoplasm.