MEG3 is a potential tumor suppressor gene in several cancer types, mainly through the observation that MEG3 expression is lower in various tumor tissues compared with non-tumor tissues of the same origin (Sheng et al., 2014; Sun et al., 2014, 2016; Yin et al., 2015; Chak et al., 2017; Molina-Pinelo et al., 2018). Here, MEG3 is linked to cancer.