FLT4 and neoplasm: TSPAN29 promotes angiogenesis and lymphangiogenesis via forming functional complexes between VEGFR-3 and integrin α5 and α9, therefore, tumor-induced and inflammation-induced lymphangiogenesis, and tumor-induced angiogenesis are decreased in TSPAN29-KO mice (Iwasaki et al., 2013) (Supplementary Table 1).