For example, in some dystroglycanopathies a significant reduction of α-DG glycosylation (hypoglycosylation) leads to a drop in laminin binding affinity, inducing severe muscular dystrophy phenotypes such as Walker-Warburg Syndrome or Muscle-Eye-Brain disease (Falsaperla et al., 2016; Brancaccio, 2019). The gene discussed is LAMB2; the disease is muscular dystrophy-dystroglycanopathy, type A.