AGRN and myocardial infarction: What is certain is that administration of exogenous agrin promotes the activation of this specific CMs proliferation program in mouse and possibly in larger mammals, as proposed by Baehr et al. in a very recent preprint manuscript (Baehr et al., 2019) reporting the regenerative effect of intracoronary injection of agrin into porcine models of myocardial infarction.