Both in mouse (Bassat et al., 2017) and porcine (Baehr et al., 2019) models of myocardial infarction (MI), recombinant agrin injected locally in the damaged heart seems to have an overall cardioprotective effect, with anti-inflammatory and angiogenic components to add to CM protection and (mild) proliferation induction. This evidence concerns the gene AGRN and myocardial infarction.