Retroviral strategies for a prolonged delivery of a series of therapeutic “mini-agrin” peptides (capable of binding both laminin and dystroglycan) have been recently proposed for the treatment of chronic pathologies such as congenital muscular dystrophies in available mouse model systems (Qiao et al., 2018; Yurchenco and McKee, 2019). Here, LAMB2 is linked to muscular dystrophy.