The phosphatidylinositol 3 kinase (PI3K)/Akt murine thymoma viral oncogene (AKT)/mammalian target of rapamycin inhibitor (mTOR) pathway drives anti-apoptotic signaling and cell division in BC through activating point mutations, somatic copy number abnormalities, and increased gene expression (9). Here, AKT1 is linked to breast cancer.