Model 2 showed a remarkable increase of the statistical power likelihood ratio (LR), 27.67 compared to 12.23 of Model 1 based exclusively on three novel IHC indicators: better OS was predicted by higher CD8+SATB1+ cell density in the tumor compartment and higher entropy (intratumoral heterogeneity) of PR expression; worse OS was predicted by the bimodality (AshD) of Ki67 expression in the tumor tissue. This evidence concerns the gene MKI67 and neoplasm.