Factor 1 was characterized by strong loadings of CD8+ and CD8+SATB1+ cell densities within the tumor and stroma compartments, factor 2 by the percentage of PR, PR AshD and entropy indicators; factor 3 by the percentage of Ki67 and Ki67 entropy indicators; factor 4 by ER entropy and factor 5 by ER bimodality. This evidence concerns the gene ESR1 and neoplasm.