To estimate the added prognostic value of the novel IHC indicators, the analyses were performed in 2 datasets: Model 1 was generated from a subset consisting of the age group, pathology characteristics (pT, pN status and histological grade) and the global IHC DIA indicators (ER, PR, HER2 and Ki67 expression rates in the tumor compartment). This evidence concerns the gene ERBB2 and neoplasm.