COL1A1, a major component of collagen type I, is upregulated and is associated with tumor metastasis in various cancers, such as breast cancer (14), hepatocellular carcinoma (17), gastric cancer (15), CRC (12), non-small-cell lung cancer (13), prostate cancer (18), and cervical cancer (16). This evidence concerns the gene COL1A1 and hepatocellular carcinoma.