COL1A1, a major component of collagen type I, is upregulated and is associated with tumor metastasis in various cancers, such as breast cancer (14), hepatocellular carcinoma (17), gastric cancer (15), CRC (12), non-small-cell lung cancer (13), prostate cancer (18), and cervical cancer (16). The gene discussed is COL1A1; the disease is colorectal carcinoma.