Indeed, in HEK293 cells, transiently or stably transfected with BCMA, we have reported that APRIL induces the canonical NF-κB pathway, together with JNK, p38, and ERK kinases (69), while, in hepatocellular carcinoma cell lines (HepG2 and Hep3B), activation of BCMA leads to the activation of a novel pathway, involving JNK2-FOXO3A-GADD45, leading to cell cycle arrest and a modest decrease of proliferation (70). The gene discussed is TNFRSF17; the disease is hepatocellular carcinoma.