In 2008, there were 27 clinical trials listed testing the use of p38 inhibitors in inflammatory disease settings205, while a search today for p38 inhibitors in clinicaltrials.gov returns 44 studies for conditions as diverse as pain, asthma, cognitive impairment, rheumatoid arthritis, cancer, myelodysplastic syndrome, and depression (Table 5). This evidence concerns the gene MAPK14 and Cognitive impairment.