MAPK14 and major depressive disorder: In 2008, there were 27 clinical trials listed testing the use of p38 inhibitors in inflammatory disease settings205, while a search today for p38 inhibitors in clinicaltrials.gov returns 44 studies for conditions as diverse as pain, asthma, cognitive impairment, rheumatoid arthritis, cancer, myelodysplastic syndrome, and depression (Table 5).