<h4>Background</h4>CD59 deficiency is a congenital mutation disorder in complement pathway which can present with various manifestations.<h4>Case presentation</h4>Herein, we presented an adolescent 16-years-old girl with recurrent attacks of Guillain-Barre in early childhood and then recurrent attacks of angioedema, paresthesia, and myelitis. Here, CD59 is linked to myelitis.