TNF and glioblastoma: Additional abnormally methylated genes have also been identified in GBM: NPY, TNF, FOXA1, KCNC3, and CASP8 [36], and another study identified 251 hypomethylated upregulated genes (Hypo-UGs) and 199 hypermethylated downregulated genes (Hyper-DGs) in GBM [33].