Six of these TFs were themselves differentially expressed in GBM and were, therefore, identified as KDETF: homeobox A3 (HOXA3), engrailed homeobox 1 (EN1), Zic family member 1 (ZIC1), and forkhead box D3 (FOXD3) were upregulated, while hepatic leukemia factor (HLF) and early growth response protein 3 (EGR3) were downregulated. The gene discussed is EGR3; the disease is glioblastoma.