Summarizing these criteria, most authors suggest a search for germline mutations in patients with PC and one of the following criteria: age <55 years; immediate relatives with PC; family history of already identified BRCA1/2 mutations or breast, ovarian, or pancreatic cancer; and PC with Gleason score >7 in the presence of signs of hereditary PC according to NCCN guidelines [70]. This evidence concerns the gene BRCA1 and pachyonychia congenita.