In general, according to the recommendations of the National Comprehensive Cancer Network (NCCN; v.2.2019), it is preferable to use NGS to sequence the multigene panel, which includes at least MMR genes mutated in Lynch syndrome and a number of other DNA-repair genes (BRCA2, BRCA1, ATM, CHEK2, PALB2, MLH1, MSH2, MSH6, and PMS2). This evidence concerns the gene MSH2 and Lynch syndrome.