We previously showed that the highly selective catalytic inhibitors GSK and ORYZON target LSD1 exclusively via the FAD domain (23); these catalytic LSD1 inhibitors have shown disappointing efficacy in the treatment of solid tumors such as metastatic melanoma, metastatic breast cancer, and Ewing sarcoma (55) due to targeting the FAD domain alone. Here, KDM1A is linked to Ewing sarcoma.