Similarly, top 500 DE genes (based on p-values) were identified for clinical conditions indicative of inflammatory exposure, namely HCA vs. no HCA; FIRS vs. no FIRS, PTL/PPROM vs. physician-initiated delivery, and laboratory signs of early inflammation (elevated CRP/IL-6) vs. no such signs. This evidence concerns the gene IL6 and preterm premature rupture of the membranes.