Similarly, knock down of Jun N-terminal kinase 12 (JNK-1/2) from KCs reversed liver fibrosis in a choline-deficient L-aminoacid-defined (CDAA) model, with a decline in inflammatory responses, including TNF-α, IL6, IL-1β, and TGF-β (30). The gene discussed is IL6; the disease is Hepatic fibrosis.