DJ-1-binding compounds, including UCP0045037/compound A, UCP0054278/compound B, and compound-23 identified from the university compound library and zinc compound library, prevent superfluous oxidation of DJ-1 and maintain reduced DJ-1, which inhibits oxidative stress-induced toxicity in in vitro and in vivo PD and stroke models (104, 105). The gene discussed is PARK7; the disease is stroke disorder.