In our study, the reduced protein expression of PPAR δ/β and PGC1-α in our animal model of T2DM is consistent with the reduced gene expression of PPAR δ/β and PGC1-α that has been reported in patients with T2DM (Mensink et al., 2007) in comparison to control obese. The gene discussed is PPARGC1A; the disease is type 2 diabetes mellitus.