AGT and triple-A syndrome: Timp3-deficiency suppressed the hypertensive response to Ang II (Basu et al., 2013), however induced abdominal aortic aneurysm (AAA) after 4 weeks of Ang II infusion (Figure 2), due to degradation of the elastin fibers and adverse remodeling of the aortic wall (Basu et al., 2012).