Timp3-deficiency suppressed the hypertensive response to Ang II (Basu et al., 2013), however induced abdominal aortic aneurysm (AAA) after 4 weeks of Ang II infusion (Figure 2), due to degradation of the elastin fibers and adverse remodeling of the aortic wall (Basu et al., 2012). This evidence concerns the gene TIMP3 and triple-A syndrome.