However, TIMP3 (S156C) expression in porcine aortic endothelial cells enhanced VEGF binding to VEGFR2 and VEGF-induced angiogenesis through up-regulation of VEGFR2 (Qi et al., 2009), which might lead to choroidal neovascularization in SFD. The gene discussed is TIMP3; the disease is Sorsby fundus dystrophy.