Due to the important role of TIMP3 in cardiac structure and function, and the severe adverse outcomes of Timp3-deficiency in heart disease (Fedak et al., 2004; Kassiri et al., 2005; Kandalam et al., 2010; Basu et al., 2012, 2013; Moore et al., 2012; Fan et al., 2014), treatment with TIMP3 could be a potential therapeutic method in these diseases. Here, TIMP3 is linked to heart disorder.