Further, a marked but transient rise in MMP activity in the early post-MI phase was found to be responsible for the adverse remodeling and increased rate of LV rupture in Timp3–/– mice, since early treatment with a broad-spectrum MMP inhibitor ameliorated the adverse LV remodeling and rupture (Kandalam et al., 2010). Here, TIMP3 is linked to myocardial infarction.