TIMP3 and myocardial infarction: In a mouse model of MI, human TIMP3-expressing adenovirus (Ad-hTIMP3) was introduced into the peri-infarct myocardium by direct injections using a 36-gauge needle, increased TIMP3 mRNA and protein could be detected in the infarct and peri-infarcted myocardium (Takawale et al., 2017).