Notably, following downregulation of GLUT4, SGLT1 may mediate glucose utilization, as it is increased 2- to 3-fold in ischemic and type 2 diabetic mellitus (T2DM) hearts (Banerjee et al., 2009) and other studies have reported that SGLT1 colocalizes with GLUT1 at the sarcolemma (Turk et al., 1991; Zhou et al., 2003). This evidence concerns the gene SLC5A1 and diabetes mellitus.