This study also suggests that THC may mediate its effects through downregulating the expression of miR-let-7a-5p and miR-34a-5p that target the expression of SOCS1, NOS1, FoxP3, and CSF1R and consequently trigger immunosuppressive MDSCs and Treg as well as directly suppress inflammatory cytokines, leading to attenuation of SEB-induced ARDS in mice. This evidence concerns the gene NOS1 and acute respiratory distress syndrome.