Interestingly, in the current study, we noted that THC-mediated effect on ARDS was regulated, at least in part, through CB2 receptor, inasmuch as blocking CB2 with a CB2 antagonist (SR 144) decreased the ability of THC to induce MDSCs and Treg as well anti-inflammatory cytokines (Figures 3A, B). The gene discussed is CNR2; the disease is acute respiratory distress syndrome.