HRH3 and Alzheimer disease: Moreover, a recent study reported that H3R inverse agonist BF 2649, or selective H3R antagonist with partial H4R receptor agonist clobenpropit, significantly showed reduction in amyloid beta peptide (AβP) deposits along with marked reduction in neuronal or glial reactions in AβP infusion-induced brain pathology in a rat model (AD like pathology).