HRH3 and spindle cell hemangioma: Moreover, considering the pro-cognitive effect of non-imidazole H3R antagonist ABT-288 in several preclinical models, a further study revealed that treatment of dysregulated cognitive function associated with SCH, the schizophrenic features remained constant for the duration of the study (Hsieh et al., 2010; Coruzzi et al., 2012).