Preclinically, cognitive ameliorating effect of various non-imidazole-based H3R antagonists, as ABT-239 and A-431404 in experimental rats with cognitive impairments that is induced by ketamine and/or MK-801, demonstrated enhanced results in comparison with reference antipsychotics like risperidone or olanzapine (Brown et al., 2013). The gene discussed is HRH3; the disease is Cognitive impairment.