That SCS modulates specific vasculature-associated growth factors suggests a crosstalk between electrical stimulation and growth factor secretion (Bagetta et al., 2011; Escamilla-Sevilla et al., 2011; Seifried et al., 2013; Maioli et al., 2015; Muñoz et al., 2016), which may mediate the observed increase in laminin-positive vascular area in the cerebral cortex of SCS-treated PD rats. The gene discussed is LAMB2; the disease is Parkinson disease.