In contrast, for tauopathies such as PSP or corticobasal degeneration (CBD), primarily caused by neuronal injury driven by different isoforms of tau proteins due to abnormal phosphorylation at different amino acid groups, the cascade of mechanisms that induce neuronal loss remains unclear and the search for consistent CSF biomarkers continues. This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.