It is worth considering that CSF Nfl has been associated with increased mortality in both brain neurodegenerative disorders that feature alpha-synuclein dysregulation [PD and multiple system atrophy (MSA)], and syndromes characterized by abundant tau protein deposition (such as PSP; Constantinescu et al., 2019). The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.