EPHB1 and amyotrophic lateral sclerosis: Ephrin type B receptor 1 (EphB1) can activate an anti-inflammatory and neuroprotective response in astrocytes; however, the EphB1-ephrin-B1 pathway did not function properly in SOD1G93A mice or in astrocytes derived from stem cells in ALS patients (Tyzack et al., 2017; Figure 1).