SNCA and Parkinson disease: Interestingly, the phosphorylation of LRRK2 at S1292 is higher in SNCA−/− HEK293 cells when oligomeric but not monomeric alpha-synuclein (α-syn) is present, suggesting a link between LRRK2 S1292 phosphorylation and species of α-syn linked to pathology that could be found in PD patient-derived cells.