It is interesting to note that the S935 dephosphorylation of LRRK2 is observed both after treatment with LRRK2 kinase inhibitors that are considered potential therapeutics for PD and are currently in clinical testing (Doggett et al., 2012; Ding and Ren, 2020), as well as for several disease mutant forms of LRRK2. Here, LRRK2 is linked to Parkinson disease.