While the global picture of how LRRK2 phosphorylation levels at its various phosphorylation sites influence LRRK2 function is still incomplete, several studies have shown that changes in LRRK2 phosphorylation influences LRRK2 biochemical or cellular properties and can be correlated to changes observed in PD patients and PD models. Here, LRRK2 is linked to Parkinson disease.