LRRK2 and Parkinson disease: Most LRRK2 PD mutations are located in the catalytic core of the protein: in the ROC domain (N1437H, R1441C/G/H/S), in the COR domain (Y1699C), and in the kinase domain (G2019S, I2020T) (Funayama et al., 2005; Healy et al., 2008; Aasly et al., 2010; Mata et al., 2016; Nucifora et al., 2016).