CYCS and neoplasm: BAX, which belongs to bcl-2 family, is a tumour suppressor and an essential effector of the mitochondrial apoptotic pathways whereby its activation by p53 (best known for its role in causing cell cycle arrest or apoptosis) signal results in the release of cytochrome c and second mitochondria-derived activator of caspases/direct inhibitor of apoptosis-binding protein with low pI (Smac/DIABLO) from mitochondria, which facilitates caspase activation and subsequent nuclear fragmentation [54, 55].