NDRG1 and breast cancer: NDRG1 was up-regulated in cybrids with cancer cell–derived mitochondria (2.7-fold change in c-SUM-159 vs c-A1N4).13 Comparing NDRG1 gene expression across breast cancer subtypes, it was observed that median expression of NDRG1 was much greater in the basal triple-negative subtype (Figure 2B and C) in both the TCGA and METABRIC13 datasets (Figure 2B and C).