On the other hand, no significant differences were found between the three levels of physical activity for the ER and HER2 status (p = 0.283), the median time between diagnosis and metastatic disease (< 24 months versus ≥ 24 months) (p = 0.302), the others metastatic localizations and the number of metastatic sites (< 3 sites versus ≥ 3 sites) (p = 0.067). The gene discussed is ESR1; the disease is metastatic neoplasm.