NR1H4 and atherosclerosis: Top canonical pathways, identified by Ingenuity Pathways Analysis, such as LXR/RXR, FXR/RXR activation (− log[P-value] = 30–31) and atherosclerosis signaling (− log[P-value] = 10–11) were similarly affected in Cbs−/− mice and CBS−/− humans.