The cyclooxygenase-2 (COX-2) mediated metabolism of arachidonic acid (AA) synthesizing PGE2, PGD2 and PGF2 carry immense physiological significance due to the role of these metabolites in commencing inflammatory diseases including cardiac, cancer, arthritis, diabetes and neurological disorders1–6. The gene discussed is PTGS2; the disease is arthritic joint disease.