RAG1 and colitis: As a note, no inflammation was observed in the small intestine of Rag1–/–Smarca4ΔILC3 mice, as was indicted by the increased percentages and absolute numbers of neutrophils in the large but not small intestinal LPLs of Rag1−/−Smarca4ΔILC3mice compared to controls, implying microbiota may be involved in the onset of colitis (Figs. 4d, e, S4b, c).