SMARCA4 and colitis: Secondly, pro-inflammatory properties of myeloid cells, which are critical in exacerbation of colitis, could be inhibited by the adaptive immune cells.52 For instance, α-CD40 induces colitis only in immunocompromised mice.60,61 Another example is that spontaneous colitis happened in Rag1−/−Tbx21−/− mice (TRUC mice) but not in Tbx21−/− mice.8,62 However, it is likely that deficiency of Brg1 in ILC3s and Tregs collectively contribute to possible intestinal inflammation in aged Smarca4ΔILC3 mice.