CD274 and cancer: Immune checkpoints are molecules of coinhibitory signaling pathways that act to maintain immune tolerance, yet they are often utilized by cancer cells to evade immunosurveillance.72,73 ICIs are designed to reinvigorate antitumor immune responses by interrupting coinhibitory signaling pathways and to promote immune-mediated elimination of malignant cells.74,75 The most widely used targets for ICIs are cytotoxic T lymphocyte-associated molecule-4 (CTLA-4), programmed cell death receptor-1 (PD-1), and programmed cell death ligand-1 (PD-L1).