cDCs consist of two subtypes, described as cDC1s and cDC2s, which demonstrate different phenotypes, functions, and transcriptional factor dependencies.162 cDC1s are specialized in presenting antigens on MHC class I molecules to CD8 T cells, while cDC2s are proficient in presenting antigens on MHC class II molecules to CD4 T cells.163 cDC1s contribute to antitumor immunity through local effects within the TME and by antigen delivery to tumor-draining lymph nodes (dLNs). The gene discussed is CD4; the disease is neoplasm.