RPTOR and granular corneal dystrophy type II: Indeed, we showed enhanced expression of p-Raptor, a component of mTORC1, and p-4EBP, a downstream effector of mTORC1 signaling, in duodenal samples of ACD as compared to normal controls while expression of p-Rictor, an indicator of mTORC2 complex activation, did not differ between ACD and controls.