IL21 and granular corneal dystrophy type II: Support to this hypothesis comes from the demonstration that both IFN-γ and IL-21, two cytokines over-produced by gluten-specific Th1 cells in ACD10,12, were able to enhance p-4EBP in ICD duodenal samples while blockade of these two molecules with neutralising antibodies reduced p-4EBP in cultures of ACD biopsy samples.