NR4A2 and Parkinson disease: In addition, Na chang et al. reported that Nurr1 overexpression exerts neuroprotective and anti-inflammatory roles via down-regulating CCL2 in both in vivo and in vitro PD models23, and Jodeiri et al. found that Nurr1 agonists protect cells against MPP + induced toxicity through anti-inflammatory and anti-mitochondrial impairment24.