Till now, a lot of genes involved in the pathogenesis of MM have been revealed such as MITF18, CPEB419, BRAF20, Flot221, and KIT22, and some corresponding targeted drugs, such as vemurafenib23,24 (BRAF inhibitor) and imatinib mesylate25 (KIT inhibitor) have been developed for the treatment of melanoma. The gene discussed is BRAF; the disease is melanoma.