Increases in inflammatory cytokines, an imbalance in muscle protein synthesis/degradation, reduced physical activity, an insufficient nutritional intake, metabolic acidosis, vitamin D deficiency, insulin resistance, excessive myostatin expression, increases in intramuscular angiotensin and decrease and dysfunction in satellite cells have been suggested as factors involved in the development of sarcopenia in chronic kidney disease patients17. The gene discussed is MSTN; the disease is chronic kidney disease.