After infection, the transcription levels of PI3K and Akt were similar in the Axl−/− and control macrophages (data not shown), but the PI3K inhibitors PI3KIP1 and WDR91 as well as the Akt inhibitor TRIB3 showed increased expression in the Axl−/− macrophages compared with that observed in the control macrophages (Table 1), suggesting that during infection, PI3K-Akt signaling may be inhibited in Axl−/− macrophages. Here, AKT1 is linked to infection.