One patient who developed facial palsy received medium dose prednisone; still, no worsening of his HIV infection was observed.24 Furthermore, in a randomized, double-blind, placebo-controlled, phase I dose-escalating study testing PD-1 inhibition (nivolumab) in HAART-treated HIV-infected adults without concurrent cancer (n=8), even a single, low-dose infusion appeared to enhance HIV-specific immunity.25 The gene discussed is PDCD1; the disease is cancer.