Based on the observation of cytokine excess (eg, TNF-α), during advanced stages of COVID-19, one may speculate that TNF-α blockers such as infliximab may not only be beneficial for the management of ICI-induced irAEs, but also for COVID-19.84 Notably, cytokine IL-6 antibodies (eg, tocilizumab) are currently under intense investigation in patients with COVID-19. The gene discussed is IL6; the disease is COVID-19.